ea0049ep435 | Diabetes (to include epidemiology, pathophysiology) | ECE2017
Barrios Vicente
, Vinaixa Maria
, Frago Laura M.
, Canelles Sandra
, Valverde Angela M.
, Argente Jesus
, Yanes Oscar
Background: IRS2-deficient (IRS2-/-) mice are considered a good model to analyze the development of diabetes as some of them present an increase in glycemia comparable to that observed in diabetes onset in humans, whereas a high proportion of these mice do not develop diabetes. Energy homeostasis regulation by the hypothalamus can be disturbed by an inflammatory environment, which predisposes an individual to the onset of diabetes. Saturated fatty acids induce hypot...